ABSTRACT
Corydalis amabilis Migo total alkaloids (COAMTA) possessed antihypertensive and vaso-dilatative action in animal experiments. Its effects on the physiological properties in isolated guinea pig papillary muscles & atrium preparations were described in this papar.10mg/L COAMTA markedly prolonged the functional refractory period(FRP) and inhibited epinephrine induced automaticity. Suppression of normal & abnormal automaticity and prolongation of FRP may contribute to the effectiveness of COAMTA on arrhythmia.
ABSTRACT
Sophoramine ( Sa ) is an alkaloid from sophora alopecuroides. Linn., in anesthetize animals ( cat, rat and rabbit), intravenous adminstra-tion of Sa reduced rapidly and markly the arterial blood pressure. The mechanism of hypotension effect of Sa is mainly attributable to its sympathetic ganglionic blocking and direct vasodilatation. Experiment on the isolated hearts of guinea pig revealed that Sa produced negative chronotropic and positive inotropic action, and increased coronary flow simultaneously.In a study of experimental arrhythmia in animals,we observed that Sa could reduce the arrhythmia induced by aconitine in rats and decreased the incidence of ventricular fibrillation induced by chloroform in mice.
ABSTRACT
Sophocarpine ( SC ) , an alkaloid extracted from sophora alope -curoides L. , was found to have a rapid and significant hypotensive action both in anesthetized dogs and in conscious renal hypertensive rats. On superior cervical ganglia and nictitating membrane preparation ,SC 15mg, administered via lingual artery, briefly relaxes the rigid contraction of nictitating membrane caused by continuous stimulation of sympathetic preganglionic fibers. SC 50, 100, 200?g/kg reduced the vascular resistance index 13.1 ?1.6%, 20.5?4.6%, 27.8?4.1% respectively when perfused into the femoral artery .Measurement of the changes of hemodynamics with constant voltage transthoracic admittance plethysmograph in 5 intact anesthetized dogs showed that SC iv 25mg/ kg enhenced the index of myocardial contractility 18% and heart beat index 40%, shortened Q -Y interval 37%.These results suggest that hypotensive action of SC should be realized by both relaxing the peripheral vascular smooth muscules and blocking the transmission of impulse through the sympathetic ganglia.
ABSTRACT
Corydalis amabilis Migo total alkaloid (COAMTA) given in vitro or in vivo caused an inhibition on ADP-induced blood platelet aggregation. In vitro, COAMTA 15.6, 31.3 & 62.5 ?g/ml PRP showed their inhibitory rates of 8.2, 32.0, & 36.8%. In vivo, at 10, 20, 40 min after iv COAMTA ( 0.6 mg/kg ) , the rates of inhibition were 40, 62.8, 24%.The thrombi formed in vitro were measured also. The results showed that COAMTA given in vitro or in vivo reduced the length and weight of thrombus, at same time, reduced rat platelet adhesion.A carotid-jugular extracorporeal shunt was made in the rats. A 6cm length of silk thread was placed in the shunt. 15 min after the restoration of blood flow in the shunt, the Wet weight of thrombus developed on the thread was measured.The thrombus weight was significantly reduced when COAMTA was given iv 0.3, & 0.6 mg/kg, im 0.9 mg/kg & po 1.5 mg/kg. The thrombus weight of control group was 26.1?0.7, but that of the medicated group was 8.9?1.7, 18.0?1.3, 16.4?0,6 a & 19.7?0.7 mg. The inhibitory rates were 66.1, 31.3, 37.2, & 28.4%.